Molecular interactions between general anesthetics and the 5HT2Breceptor
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چکیده
منابع مشابه
Molecular interactions between inhaled anesthetics and proteins.
The fundamental interactions of inhalational anesthetics with proteins have been considered in some detail, using specific examples where appropriate to illustrate these interactions and demonstrate progress. It is now clear that these low-affinity volatile molecules with rapid kinetics can specifically bind to discrete sites in some proteins at reasonable pharmacological concentrations, and so...
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The term ‘‘anesthesia’’ was originally used by the ancient Greek surgeon Dioscorides and resurrected by Dr Oliver Wendell Holmes to describe the insensible state produced by inhalation of ether. The goals of general anesthesia include amnesia, unconsciousness (also termed hypnosis), and immobilization. By definition, general anesthetics reversibly produce all 3 of these therapeutic effects. Gen...
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Current concepts of the molecular and cellular mechanisms that underlie general anesthetic actions are incomplete. This is both surprising, given that leading scientists have approached this problem for more than a century, and unfortunate since this lack of knowledge limits our ability to employ these important drugs with optimal safety and efficacy. Considerable evidence now implicates agent-...
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ژورنال
عنوان ژورنال: Journal of Biomolecular Structure and Dynamics
سال: 2013
ISSN: 0739-1102,1538-0254
DOI: 10.1080/07391102.2013.869483